Intermittent Fasting for Crohn’s Disease: New Clinical Evidence on Time-Restricted Feeding

The Science of Timing: How 16:8 Fasting Impacts Crohn’s Disease

Recent clinical research has uncovered a powerful new tool for managing Crohn’s disease that doesn’t involve changing what you eat, but rather when you eat. A randomized controlled trial led by the University of Calgary and funded by the Crohn’s & Colitis Foundation has demonstrated that Time-Restricted Feeding (TRF) can significantly lower disease activity and systemic inflammation.

Key Findings from the Study

In a 12-week trial involving adults with Crohn’s disease and overweight/obesity, those who followed an 8-hour eating window experienced:

40% reduction in Crohn’s disease activity.
50% decrease in abdominal discomfort.
Significant weight loss (average 5.5 lbs) without calorie counting.
Reduced inflammation markers, specifically lower levels of leptin and PAI-1.

How Time-Restricted Feeding Works for IBD

TRF, often referred to as the 16:8 method, involves consuming all daily calories within a consistent 8-hour window (e.g., 10:00 AM to 6:00 PM) and fasting for the remaining 16 hours.

Unlike traditional diets, the benefits seen in this study were not solely due to weight loss or calorie restriction. Researchers observed favorable shifts in gut bacteria and a reduction in harmful visceral fat, suggesting that the fasting period allows the digestive system to rest and the immune system to recalibrate.

Expert Perspective

"This study shows that while weight loss is an important outcome... time-restricted feeding offers additional benefits beyond just the scale," says Dr. Maitreyi Raman, Associate Professor of Medicine at the University of Calgary. "We saw meaningful improvements in disease symptoms... suggesting that intermittent fasting may help patients maintain lasting remission."

Is It Right For You?

While the results are promising, it is critical for individuals with Inflammatory Bowel Disease (IBD) to consult their healthcare provider before starting a fasting regimen. TRF may not be suitable for everyone, especially those at risk of malnutrition or those with specific medical requirements.

Summary Table: The 16:8 Protocol for Crohn’s

Feeding Window: 8 hours (e.g., 11 AM - 7 PM)
Fasting Window: 16 hours (water, black coffee, or plain tea allowed)
Primary Benefit: Reduced systemic inflammation and symptom relief.
Duration for Results: 12 weeks according to the clinical trial.

Reference: Study published in Gastroenterology (February 2026) by University of Calgary and Crohn’s & Colitis Foundation.